• Yuan, Zixuan, Pavel MA, Hansen, SB Title: GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons. (2024)  BioRxiv
  • Petersen EN, Pavel MA, Hansen SS, Gudheti M, Ferris HA, Murphy KR, Ja WW, Jorgensen EM, Hansen SB. Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling. (2024) eLife Jan 24,doi: 10.7554/eLife.89465
  • Hansen SB, Yuan Z (2023) Getting in on the action: New tools to see SARS-CoV-2 infect a cell. Cell Chem Biol 30, 233–234.
  • Yuan Z, Hansen SB (2023) Cholesterol Regulation of Membrane Proteins Revealed by Two-Color Super-Resolution Imaging. Membranes (Basel) 13, 250.
  • Wang H, Yuan Z, Pavel MA, Jablonski SM, Jablonski J, Hobson R, Valente S, Reddy CB, Hansen SB (2023) The role of high cholesterol in SARS-CoV-2 infectivity. J Biol Chem 104763.
  • Wing PA, Schmidt NM, Peters R, Erdmann M, Brown R, Wang H, Swadling L, Newman J, Thakur N, Shionoya K, Morgan SB, Hinks TS, Watashi K, Bailey D, Hansen SB, Davidson AD, Maini MK, McKeating JA (2023) An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity. PLOS Pathog 19, e1011323.
  • Yuan Z, Pavel MA, Wang H, Kwachukwu J, Mediouni S, Jablonski JA, Nettles K, Reddy CB, Valente ST, Hansen SB (2022) Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture. Communications Biology 5:958
  • Wang H, Kulas J, Wang C, Holtzman DA, Ferria HA, Hansen SB (2021) Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. Proc. Natl. Acad. Sci. 118, e2102191118  
  • Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD (2020) Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell 79(1):68-83.e7.
  • Pavel MA, Petersen EN, Wang H, Lerner RA Hansen SB (2020) Studies on the mechanism of general anesthesia. Proceedings of the National Academy of Sciences 117(24)13757-13766
  • Wang H, Yuan Z, Pavel MA, Hansen SB (2020) The role of high cholesterol in age-related COVID19 lethality. bioRxiv; doi: 10.1101/2020.05.09.086249
  • Petersen EN, Pavel MA, Wang H, Hansen SB (2020) Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels. BBA Biomembranes 1862(1)1-9
  • Petersen EN, Gudheti M, Pavel MA, Murphy KR, Ja SW, Jorgensen EM, Hansen SB (2019) Phospholipase D Transduces Force to TREK-1 Channels in a Biological Membrane. BioRxiv;
  • Pavel MA, Chung HW,Petersen EN., Hansen SB (2019) Polymodal Mechanism for TREK-1 Inhibition by Local Anesthetic. Anesth. & Analg. 129(4):973-982.
  • Robinson CV, RohacsT, and Hansen SB (2019) Tools for understanding nanoscale lipid regulation of ion channels. 2019 Trends Biochem Sci. 44(9):795-806.
  • Chung HW, Petersen EN, Cabanos C, Murphy KR, Pavel AP, Hansen AS, Ja WW, Hansen SB (2018) A Molecular Target for an Alcohol Chain-length Cutoff (2019) J Mol Biol. 431(2):196-209. 
  • Nayebosadri A, Petersen EN, Cabanos C, Hansen SB (2018) A Membrane Thickness Sensor in TREK-1 Channels Transduces Mechanical Force. Cell. doi:10.2139/ssrn.3155650
  • Cabanos C, Wang M, Han X, Hansen SB (2017) A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels. Cell Rep 20(6):1287–1294. 
  • E. Nicholas Peteresen, Hae-Wng Chung, Arman Nayebosadri, and Scott B. Hansen “Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D” Nature Commun. 2016 Dec (7) 13873; 
  • Hansen SB “Lipid Agonism; the PIP2 Paradigm of ligand gated ion channels” Biochim Biophys Acta 2015 May 1851 (5): 620-628. 
  • Hansen SB, Xiao Tao, Roderick MacKinnon “Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2” Nature 2011, 477:495-98
  • Hansen SB, Wang, HL, Taylor P, and Sine SM “An Ion-Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance. J Biol Chem. 2008 Dec 26:283(52):36066-70
  • Gao F, Mer G, Tonelli M, Hansen SB, Burghart TP, Taylor P, Sine SM. “Solution NMR of Acetycholine Binding Protein Reveals ACh-mediated Conformational Change of the C-loop” Mol Pharmacol. 2006 Oct 70(4): 1230-5
  • Hansen SB and Taylor P “Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-a-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors” J. Mol. Biol. 2007 June 369, 895-901 
  • Bourne Y, Talley TT, Hansen SB, Taylor P and Marchot P “Crystal structure of a Cbtx-AChBP complex reveals essential interaction between snake a-neurotoxins and nicotinic receptors” Embo J 2005, 24: 1512-22
  • Hibbs RE, Johnson DA, Shi J, Hansen SB, and Taylor P “Structural Dynamics of the a-Neurotoxin-Acetylcholine Binding Protein Complex: Hydrodynamic and Fluorescence Anisotropy Decay Analyses” Biochemistry 2005, 44:16602-11
  • Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y “Structures of Aplysia AChBP complexes with agonists and antagonists reveal distinctive binding interfaces and conformations” Embo J 2005, 24:3635-46
  • Gao F, Bren N, Burghardt TP, Hansen SB, Henchman RH, Taylor P, McCammon JA, Sine SM. “Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence” J Biol Chem. 2005 Mar 4;280(9):8443-51
  • Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, and Sine SM “Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel” Nature 2004 Aug 19:430:896-900
  • Hansen SB, Talley TT, Radic Z, and Taylor P. “Structural and ligand recognition characteristics of an acetylcholine binding protein from Aplysia californica” J Biol Chem. 2004 Jun 4:279(23):24197-202
  • Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, and Sine SM. “Curariform antagonists bind in different orientations to acetylcholine-binding protein” J Biol Chem. 2003 Jun 20;278(25):23020-6.
  • Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, and Taylor P. “Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein” J Biol Chem. 2002 Nov 1;277(44):41299-302.

Issued Patents

Hansen SB, Radic Z, and Taylor P “Methods for identifying agents that modulate LGIC receptor activity.” United States Patent 7947466. 24 May 2011

Hansen SB, Hansen AS “Methods for identifying molecules that modulate lipid binding sites of ion channels” United States Patent 8669065. 11 March 2014